Explore our innovative
Organ-on-Chip technology
Organ-on-Chip technology represents a cutting-edge in vitro testing system for drug development, effectively simulating the functions of human organs. By providing more accurate test results, this innovative approach accelerates the drug development process while significantly reducing experimental costs. It paves the way for safer and more efficient therapeutic solutions.
Traditional
cell culture
✘ Simulated physiology
✘ Intercellular interactions
✔ Gene differences regulation
Traditional
animal testing
✔ Simulated physiology
✔ Intercellular interactions
✘ Gene differences regulation
Organ-on-Chip
✔ Simulated physiology
✔ Intercellular interactions
✔ Gene differences regulation
CORE TECHNOLOGY
Technical Highlights
Organ-on-Chip technology integrates multiple disciplines, including microfluidics, microfabrication, biomaterials engineering, and biology, to create a sophisticated microphysiological environment. This innovative system offers a testing platform that closely mimics real human physiological conditions.
Traditional 2D or 3D cell cultures often lack key physiological functions such as membrane contractions, lung alveolar movements, muscle contractions, circulation simulation, and essential intercellular interactions. Additionally, animal testing can introduce variability due to genetic differences.
By replacing conventional cell cultures and animal testing, Organ-on-Chip technology opens up new avenues for biomedical research, drug development, and personalized medicine, providing more accurate and relevant results for advancing healthcare solutions.
Tumor Microenvironment (TME) Chip
The TME-chip is an advanced bio-chip designed to create a dynamic tumor microenvironment. The TME-chip faithfully recreates a pathological environment in 3D space, effectively mimicking the structure and composition of a cold tumor in vitro. It is particularly valuable for drug and toxin testing, with its current clinical applications focusing on drug testing for non-small cell lung cancer, especially in relation to combined therapies involving chemotherapy and immunotherapy.
The image of TME-Chip with different cell types distribution
The survival status of A549 cells on the chip with treatment of pemetrexed and atezolizumab.
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The image of TME-Chip with different cell types distribution and drug treatment.
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