Turning Biological Complexity
into Precise Decision
Human-Relevant Models. Actionable Insights. Better Decisions.
We combine proprietary TME-Chip technology with deep expertise in oncology drug development, translational research, biomarker strategy, and multi-omics integration. We partner with biopharmaceutical companies, academic medical centers, translational research laboratories, and clinical investigators to generate biologically relevant data and actionable insights that support drug development and precision oncology programs.
OUR PRODUCTS
Tumor Microenvironment Chip (TME-Chip)
Recreating the Tumor Microenvironment for Predictive Oncology Research
Pythia’s propriety TME-Chip combines 3D culture, dynamic perfusion, and compartmentalized tumor–stroma–immune interactions to recreate key features of the human tumor microenvironment. The platform supports drug penetration studies, immune migration analysis, real-time imaging, media sampling, and biomarker discovery to generate translationally relevant data for predictive oncology research.
KEY FEATURES
3D Culture
Supports tumor spheroids, organoids, and multicellular co-culture models to better mimic the architecture of human tumors.
Dynamic Perfusion
The central perfusion channel provides a stable and controlled flow environment, simulating nutrient delivery, metabolite exchange, and drug transport found in vivo.
Tumor-Stroma-Immune Interactioin
Recreates cellular crosstalk within the tumor microenvironment, enabling the study of immune responses and tumor biology.
Real-time Quantitative Analysis
Monitor treatment responses through live imaging, media sampling, and biochemical assays, enabling dynamic assessment of cellular behavior and therapeutic effects.
TME-Chip Perfusion Hub
Six TME-Chips. One Smart Controller.
A user-friendly perfusion platform designed to deliver physiologically relevant flow, scalable parallel experimentation, and automated control for tumor microenvironment research.
KEY FEATURES
PARALLEL PERFUSION
Run up to 6 TME-Chips simultaneously for control, treatment and combination studies.
PRECISE FLOW CONTROL
Integrated controlled enables precise flow rate and customizable perfusion profiles.
BUILT FOR TRANSLATION
Designed for oncology drug discovery, immunotherapy evaluation, ADC studies, and patient-derived models.
USER-FRIENDLY DESIGN
Intuitive setup and compact footprint for both academic, translational and biopharma environment
OUR SERVICES
Service Workflow
From Your Question to Actionable Development Insights
We work closely with you from the understanding your scientific question,
designing the right study,and translating complex biological data into insights
that support better oncology drug development or treatment decisions.
We first work with you to understand your scientific question, therapeutic candidate, target indication, and development goals, then design a customized TME-Chip study with appropriate models, controls, treatment conditions, and readouts.
Clinically relevant biological samples and investigational therapies are prepared for testing, including small molecules, antibodies, ADCs, immunotherapies, or combination treatments.
Recreate key interactions between tumor, stromal, and immune cells within a dynamic microenvironment that more closely reflects human biology.
Monitor treatment response through live imaging, cellular activity, secreted biomarkers, and quantitative phenotypic measurements.
Characterize molecular changes associated with drug response, resistance mechanisms, and disease biology.
Combine phenotypic and molecular datasets to uncover biological drivers, predictive biomarkers, and translational insights.
Transform complex data into evidence-based recommendations that support smarter development decisions and precision oncology strategies.
Contact Us
Connect with Pythia Biotech to learn more about our products and services,
explore partnering opportunities, or discuss potential collaborations.
