See what happens inside the tumor
The TME-Chip is a perfused 3D culture platform for oncology research, with applications in tumor biology, drug delivery, therapeutic response, and patient-derived models. Tumor spheroids form directly on the chip, cultures can be maintained for up to two weeks, and the extracellular matrix (ECM) can be adjusted for each experiment.
01 · EXPLORE
Explore the Tumor Microenvironment
Co-culture tumor, stromal, and immune cells as 3D spheroids in a tunable ECM, with live imaging and on-chip immunostaining.
⪧Spheroid formation & long-term culture
⪧Tumor–immune interactions
⪧CAFs & extracellular matrix
02 · ASSESS
Assess Drug Penetration and Distribution
Perfuse labeled agents through 3D tumor tissue and measure how far, how fast, and how evenly they penetrate.
⪧Antibodies & ADCs
⪧Transport & exposure profiling
03 · EVALUATE
Evaluate Therapeutic Response
Test different therapeutic modalities in 3D tumor models that include stromal and immune cells.
⪧Chemotherapy & small molecules
⪧Antibody-based therapies
⪧Checkpoint inhibitors & T-cell engagers
⪧Cell therapies
⪧Combination regimens
04 · EXTEND
Extend to Patient-Derived Models
Study patient-derived samples with stromal and immune components to investigate treatment response and heterogeneity.
⪧Patient-derived samples
⪧Biomarkers
Select Your Models and Readouts
MODELS
- Tumor spheroids
- Organoids
- Tumor–immune co-culture
- Tumor–stroma co-culture
- Patient-derived tumor models
READOUTS
- Cell viability
- Immunofluorescence
- Effluent profiling
- Penetration imaging
- Time-lapse migration tracking
- Nucleic acids retrieval for DNA and RNA analysis
EXTENDED ANALYSIS WITH PARTNERS
- Multi-omics integration
- Computational and AI-assisted data analysis
Contact Us
Connect with Pythia Biotech to learn more about our products and services,
explore partnering opportunities, or discuss potential collaborations.
